This session will challenge traditional views on inflammatory disease states in orthopedics, moving beyond the myth of "wear and tear" to explore the immune processes at the root of chronic pain and inflammation. Attendees will be guided through the latest advances in treatment plans that combine GLP-1 therapies with NAD enhancement, immune-modulating peptides, and pain-controlling compounds and supplements. These innovative approaches not only address pain and inflammation but also contribute to longer health span and lifespan by reducing the impact of chronic disease states exacerbated by immune and inflammatory conditions. This session is designed to equip practitioners with the tools to create comprehensive, cutting-edge treatment plans that align with the goals of clinical longevity medicine, offering new hope for patients suffering from chronic pain and inflammation.